aladdin 阿拉丁 M414235 MKC8866 1338934-59-0 97%

中文名：MKC8866

英文名：MKC8866

纯度：Moligand™，≥97%

货号：M414235

Cas号：1338934-59-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

MKC8866 MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.

Targets

hIRE1α (Cell-free assay) 0.29 μM

In vitro

MKC8866 is optimized and refined from a family of IRE1α-specific endoribonuclease inhibitors obtained from a chemical library screen. MKC8866 effectively represses IRE1α-mediated XBP1 splicing in PCa cells and has favorable pharmacokinetic and pharmacodynamic properties.

In vivo

MKC8866 is an IRE1α RNase-specific inhibitor molecule that displays significant therapeutic activity in various preclinical models of PCa in vivo. MKC8866 synergizes with clinical PCa drugs in vivo.

Cell Research(from reference)

Cell lines：human PCa cell lines LNCaP and 22Rv1, VCaP cell line, C4-2B cell line 

Concentrations：0.2-10 μM 

Incubation Time：0.25-24 h 

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