aladdin 阿拉丁 C118797 牛促肾上腺皮质激素释放激素 92307-52-3 ≥90% (HPLC)

中文名：牛促肾上腺皮质激素释放激素

英文名：Corticotropin Releasing Factor bovine

英文别名：92307-52-3|DTXSID80856168|PUBCHEM_71581479

纯度：≥90% (HPLC)

货号：C118797

包装：1mg、5mg

Cas号：92307-52-3

存储温度：-20°C储存

产品介绍：

氨基酸序列 Ser-Gln-Glu-Pro-Pro-Ile-S?er-Leu-Asp-Leu-Thr-Phe-Hi?s-Leu-Leu-Arg-Glu-Val-Leu?-Glu-Met-Thr-Lys-Ala-Asp-?Gln-Leu-Ala-Gln-Gln-Ala-H?is-Asn-Asn-Arg-Lys-Leu-Le?u-Asp-Ile-Ala Corticotropin Releasing Factor,bovine, (C206H340N60O63S1), a peptide with the sequence H2N-SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-amide, MW= 4697.4. Corticotropin-releasing hormone (CRH) also known as corticotropin-releasing factor (CRF) is a peptide hormone and neurotransmitter involved in the stress response. It belongs to corticotropin-releasing factor family(1). Its main function is the stimulation of the pituitary synthesis of ACTH.Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Increased CRH production has been observed to be associated with Alzheimer's disease and major depression(2), and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.

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