aladdin 阿拉丁 M413715 Motolimod (VTX-2337) 926927-61-9 99%

中文名：Motolimod (VTX-2337)

英文名：Motolimod (VTX-2337)

纯度：Moligand™，≥99%

货号：M413715

Cas号：926927-61-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

Motolimod (VTX-2337) Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.

Targets

TLR8 100 nM(EC50)

In vitro

VTX-2337 stimulates the production of both TNFα with EC50 of 140 nM and IL-12 with EC50 of 120 nM in PBMCs. In monocytes and mDCs, VTX-2337 selectively induces the production of TNFα and IL-12 via NF-κB activation. VTX-2337 also stimulates IFNγ production from NK cells, augments the lytic function of NK cells and enhances ADCC.

In vivo

In an ovarian cancer mouse model, TX-2337 enhances the effect of pegylated liposomal doxorubicin (PLD).

Cell Research(from reference)

Cell lines：PBMCs or purified NK cells 

Concentrations：~500 nM 

Incubation Time：48 h 

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