aladdin 阿拉丁 R413732 RO9021 1446790-62-0 95%

中文名：RO9021

英文名：RO9021

纯度：≥95%

货号：R413732

Cas号：1446790-62-0

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

RO9021 RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.

Targets

Syk (Cell-free assay) 5.6 nM

In vitro

RO9021 suppresses BCR signaling in human peripheral blood mononuclear cells (PBMC) and whole blood, FcγR signaling in human monocytes, and FcεR signaling in human mast cells and blocks osteoclastogenesis from mouse bone marrow macrophages in vitro. Toll-like Receptor(TLR) 9 signaling in human Bcells was inhibited by RO9021, resulting in decreased levels of plasmablasts, immunoglobulin (Ig)M and IgG upon B-cell differentiation. RO9021 also potently inhibited type I interferon production by human plasmacytoid dendritic cells (pDC) upon TLR9 activation. This effect is specific to TLR9 as RO9021 did not inhibit TLR4- or JAK-STAT-mediated signaling. RO9021 does not appreciably inhibit the JAK-STAT pathway.

In vivo

Oral administration of RO9021 inhibits arthritis progression in the mCIA model.

Cell Research(from reference)

Cell lines：Human B-cell line, Ramos 

Concentrations：1 μM 

Incubation Time：5 or 15 min 

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