RABV糖蛋白Glycoprotein-ACROBiosystems百普赛斯

Rabies virus (strain CVS-11) Glycoprotein G, His Tag (MALS verified)

分子别名（Synonym）

Glycoprotein G

表达区间及表达系统（Source）

Rabies virus (strain CVS-11) Glycoprotein G, His Tag (RAG-V55H5) is expressed from Baculovirus-Insect cells.

Predicted N-terminus: Lys 20

蛋白结构（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 53.6 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

纯度（Purity）

>95% as determined by SDS-PAGE.

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

狂犬病病毒（RABV），学名狂犬病lyssavirus，是一种致命的嗜神经病毒，可导致人类和动物狂犬病。狂犬病病毒的宿主范围极广，最常通过动物唾液传播。在疾病进展之前不进行干预，狂犬病是所有传染病中病死率最高的。RABV包含一个单链负义RNA基因组，编码五种结构蛋白：核蛋白（N）、磷蛋白（P）、基质蛋白（M）、糖蛋白（G）和RNA依赖性RNA聚合酶（L）。在这些病毒蛋白中，RABV糖蛋白（RABV-G）是介导病毒进入的关键参与者，也是中和抗体的主要靶标，因此是疫苗和药物设计的关键因素。