| 名称 | Macimorelin acetate |
| 描述 | Macimorelin acetate is an orally active agonist of the GHSR (Growth Hormone Secretagogue Receptor) and functions as a growth hormone (GH) secretagogue. As a ghrelin mimetic, it potently stimulates the release of endogenous growth hormone by binding to GHSR. Macimorelin acetate is clinically utilized as a diagnostic tool for Adult Growth Hormone Deficiency (AGHD) and is being investigated for the treatment of Cancer Anorexia-Cachexia Syndrome (CACS). Additionally, it has shown potential in neurological research for suppressing seizure activity. |
| 体外活性 | NFATc1-IN-1 (0、0.5、1.0、1.5、2.0、2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.[1]
NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1.[1] |
| 体内活性 | Macimorelin acetate 在癫痫小鼠模型中(5 mg/kg, 腹腔注射)可显著抑制急性癫痫发作，但无持久抗癫痫效应 [2]。临床口服给药能快速、剂量依赖地升高 GH 水平，是诊断成人生长激素缺乏症(AGHD)的有效工具 [1]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 80 mg/mL (149.64 mM), Sonication is recommended.
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| 关键字 | UMV-1843 | UMV1843 | UMV 1843 | Macrilen | Macimorelin Acetate | Macimorelin | JMV-1843 | JMV1843 | JMV 1843 | EP-1572 acetate ; AEZS-130 Acetate | EP-1572 acetate ; AEZS130 Acetate | EP-1572 acetate ; AEZS 130 Acetate | EP-1572 acetate ; AEZS-130 acetate | EP-1572 Acetate | EP1572 Acetate | EP-1572 | EP1572 | EP 1572 Acetate | EP 1572 | D-87575 acetate | ARD-07 | ARD07 | AibDTrpDgTrpCHO. Macimorelin Acetate | AEZS-130 Acetate | AEZS130 Acetate | AEZS-130 | AEZS130 | AEZS 130 Acetate | AEZS 130 |
| 相关产品 | Obestatin (rat) acetate | Obestatin (human) | Anamorelin | Ibutamoren | CJC-1295 acetate(863288-34-0 free base) | Ibutamoren Mesylate | YIL 781 | AnaMorelin hydrochloride | Taurolithocholic Acid 3-sulfate sodium salt | L-692429 | Cortistatin-8 acetate | JMV 2959 hydrochloride (925238-89-7 free base) |
