MTHFR抗体 新品

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Western blot analysis using MTHFR mouse mAb against Rat Heart cell lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human lung cancer using MTHFR mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human intima cancer tissues (left) and prostate tissues (right) using MTHFR mouse mAb with DAB staining.    

  
  

The methylenetetrahydrofolate reductase (MTHFR) enzyme, encoded by the *MTHFR* gene, plays a critical role in folate metabolism by converting 5.10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cofactor for homocysteine remethylation to methionine. Genetic variants, particularly *C677T* (rs1801133) and *A1298C* (rs1801131), are linked to reduced enzyme activity, leading to elevated homocysteine levels and altered folate status. These polymorphisms are associated with increased risks of cardiovascular diseases, neural tube defects, pregnancy complications, and certain cancers.

MTHFR antibodies are immunological tools used in research to detect and quantify MTHFR protein expression, localization, and function in tissues or cell lines. They aid in studying the enzyme’s role in folate-homocysteine cycling, epigenetic regulation, and disease mechanisms. Commercial antibodies (polyclonal or monoclonal) are optimized for techniques like Western blotting, immunohistochemistry, or ELISA. In clinical contexts, MTHFR autoantibodies have been explored in autoimmune conditions, though their pathogenic relevance remains unclear.

Genetic testing for *MTHFR* variants, combined with homocysteine level assessments, guides personalized interventions (e.g., folate supplementation). However, antibody-based detection of MTHFR protein is primarily research-focused, complementing genetic data to elucidate molecular pathways and therapeutic targets in hyperhomocysteinemia-related disorders.