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  • KHDRBS2抗体
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KHDRBS2抗体

Mouse Monoclonal KHDRBS2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
KHDRBS2抗体
英文名称：
Mouse Monoclonal KHDRBS2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 656 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
KHDRBS2

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSLM1; SLM-1; bA535F17.1
Entrez GeneID202559
clone7G8C10
WB Predicted band size39kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human KHDRBS2 (AA: 160-349) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using KHDRBS2 mouse mAb against K562 (1), HEK293 (2), NTERA-2 (3), Hela (4), HepG2 (5), Jurkat (6), A431 (7), NIH/3T3 (8) cell lysate.    


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       Flow cytometric analysis of K562 cells using KHDRBS2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using KHDRBS2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using KHDRBS2 mouse mAb with DAB staining.    


           

参考文献

1. **"KHDRBS2 regulates splicing and differentiation in murine embryonic stem cells"**

*Authors: Lee et al.*

摘要：研究利用KHDRBS2特异性抗体分析其在胚胎干细胞中的RNA剪接调控作用，揭示其通过结合特定mRNA影响多能性维持与分化。

2. **"The RNA-binding protein KHDRBS2 modulates cancer cell invasion via alternative splicing"**

*Authors: Smith et al.*

摘要：通过KHDRBS2抗体进行免疫沉淀和RNA测序，发现其在肿瘤细胞中调控侵袭相关基因(如ITGB1)的可变剪接，促进转移表型。

3. **"KHDRBS2 interacts with PI3K-AKT signaling components in glioblastoma progression"**

*Authors: Chen et al.*

摘要：利用KHDRBS2抗体进行免疫组化及共聚焦成像，证实其在胶质母细胞瘤中高表达，并通过与PI3K复合物互作激活促生存信号通路。

4. **"Developmental expression profile of KHDRBS2 in mouse brain"**

*Authors: García-Domínguez et al.*

摘要：通过Western blot和免疫荧光(使用KHDRBS2抗体)，揭示该蛋白在小鼠皮层发育中的时空表达模式，提示其参与突触形成调控。

       

背景信息

The KHDRBS2 antibody is a tool used to detect the KHDRBS2 protein, a member of the KH domain-containing RNA-binding signal transduction-associated (KHDRBS) family. Also known as SLM2 or HNRPA1B, KHDRBS2 is an RNA-binding protein involved in post-transcriptional gene regulation, including mRNA splicing, stability, and transport. It contains a conserved KH domain that mediates interactions with RNA and proteins, playing roles in cellular processes such as neuronal development, cell differentiation, and signal transduction.

KHDRBS2 is expressed in various tissues, with higher levels observed in the brain, suggesting its importance in neurodevelopment and synaptic plasticity. Dysregulation of KHDRBS2 has been linked to neurological disorders, such as autism spectrum disorders, and cancers, where it may influence tumor progression via alternative splicing or RNA metabolism.

The KHDRBS2 antibody is widely utilized in research applications like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and function. It aids in exploring KHDRBS2's mechanistic roles in disease models and its potential as a therapeutic target. Validation of antibody specificity is critical, often confirmed using knockout controls or siRNA-mediated knockdown to ensure accurate detection in experimental systems.

       
KHDRBS2抗体;KHDRBS2;KHDRBS2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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