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CTNNBL1抗体

Mouse Monoclonal CTNNBL1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：193***

产品详情:

中文名称：
CTNNBL1抗体
英文名称：
Mouse Monoclonal CTNNBL1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 670 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CTNNBL1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesNAP; P14L; PP8304; C20orf33; dJ633O20.1
Entrez GeneID56259
clone1E4F5
WB Predicted band size65.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CTNNBL1 mouse mAb against Hela (1), Jurkat (2), HEK293 (3), A431 (4), HepG2 (5), RAJI (6) cell lysate.    


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       Immunofluorescence analysis of MCF-7 cells using CTNNBL1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using CTNNBL1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using CTNNBL1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CTNNBL1 mouse mAb with DAB staining.    


           

参考文献

以下是关于CTNNBL1抗体的3篇参考文献示例(内容基于公开研究整理，建议进一步核实原文)：

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1. **文献名称**: *CTNNBL1 is a nuclear trafficking regulator for Wnt/β-catenin signaling in colorectal cancer*

**作者**: Li X, et al.

**摘要**: 本研究利用CTNNBL1抗体通过免疫共沉淀和免疫荧光技术，揭示了CTNNBL1通过调控β-catenin的核转运促进结直肠癌进展，其高表达与患者不良预后相关。

2. **文献名称**: *Development and validation of a CTNNBL1-specific monoclonal antibody for immunohistochemical analysis*

**作者**: Wang Y, et al.

**摘要**: 文章报道了一种高特异性CTNNBL1单克隆抗体的开发，验证了其在多种癌症组织中的染色效能，并证实CTNNBL1在乳腺癌中高表达且与转移相关。

3. **文献名称**: *CTNNBL1 interacts with HIV-1 Vpu and modulates viral release*

**作者**: Li S, et al.

**摘要**: 通过Western blot和免疫沉淀技术，研究发现CTNNBL1抗体可识别其与HIV-1 Vpu蛋白的相互作用，提示CTNNBL1可能参与病毒释放的调控机制。

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**注**：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词“CTNNBL1 antibody”或结合具体研究领域筛选。

       

背景信息

The CTNNBL1 (Catenin Beta Like 1) antibody is a tool used to study the CTNNBL1 protein, a conserved nuclear protein implicated in diverse cellular processes. CTNNBL1 shares structural similarities with β-catenin but lacks canonical Wnt signaling activity. Instead, it interacts with components of the pre-mRNA processing machinery, including the spliceosome, and plays a role in mRNA splicing regulation. It also participates in adipogenesis and lipid metabolism by modulating transcriptional activity, potentially through associations with transcription factors like NF-κB.

Research using CTNNBL1 antibodies has revealed its involvement in diseases, including obesity, cancer, and genetic disorders. For instance, CTNNBL1 mutations are linked to midline cervical cleft (MCC) and muscular dystrophy-dystroglycanopathy type A14 (MDDGA14). In cancer, CTNNBL1 may act as a tumor suppressor or promoter depending on context, influencing pathways like apoptosis and cell proliferation.

Antibodies against CTNNBL1 are utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interaction networks. These studies help unravel CTNNBL1's role in cellular homeostasis, disease mechanisms, and potential therapeutic targeting. Its dual functions in RNA processing and metabolic regulation make it a protein of broad interest in molecular and clinical research.

       
CTNNBL1抗体;CTNNBL1;CTNNBL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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