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PLCG2抗体

Mouse Monoclonal PLCG2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：193***

产品详情:

中文名称：
PLCG2抗体
英文名称：
Mouse Monoclonal PLCG2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 710 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
PLCG2

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesFCAS3; APLAID; PLC-IV; PLC-gamma-2
Entrez GeneID5336
clone3A8B6
WB Predicted band size148kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human PLCG2 (AA: phospho-Tyrosine 753 of human Phospholipase Cg2(cERDINSLpYDVSRMYV)).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using PLCG2 mouse mAb against A431 cell lysate.    


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       Immunofluorescence analysis of Hela cells using PLCG2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using PLCG2 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于PLCG2抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：

1. **"PLCG2 mutations in antibody deficiency and immune dysregulation"**

**作者**: Ombrello, M.J. et al.

**摘要**: 研究揭示了PLCG2功能获得性突变与免疫失调综合征的关系，通过特异性抗体检测突变蛋白的表达水平，发现其异常激活导致B细胞信号通路紊乱，为免疫缺陷机制提供新见解。

2. **"Anti-PLCG2 monoclonal antibody inhibits rheumatoid arthritis progression in murine models"**

**作者**: Li, Z. et al.

**摘要**: 开发了一种靶向PLCG2的单克隆抗体，实验显示其能有效阻断下游炎症因子释放，显著减轻小鼠模型中的关节炎症，提示其在自身免疫疾病治疗中的潜力。

3. **"PLCG2 as a biomarker in chronic lymphocytic leukemia: antibody-based profiling study"**

**作者**: Wang, Y. et al.

**摘要**: 通过免疫组化和流式细胞术分析PLCG2在白血病细胞中的表达，证实其高表达与疾病进展相关，提出PLCG2抗体可作为预后评估的生物标志物工具。

*注：上述文献为示例，实际引用时需核实真实来源及准确性。建议通过PubMed或Web of Science以“PLCG2 antibody”或“PLCG2 signaling”等关键词检索最新研究。*

       

背景信息

The PLCG2 antibody targets phospholipase C gamma 2 (PLCG2), a key enzyme in intracellular signaling pathways, particularly within immune cells. PLCG2 is a member of the phospholipase C family, which hydrolyzes phosphatidylinositol 4.5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1.4.5-trisphosphate (IP3), critical secondary messengers regulating calcium release and protein kinase C (PKC) activation. Expressed predominantly in hematopoietic cells, PLCG2 plays a vital role in B-cell receptor (BCR) and Fc receptor (FcR) signaling, influencing immune responses, cell proliferation, and differentiation.

PLCG2 contains distinct domains, including SH2. SH3. and catalytic regions, enabling interactions with tyrosine-phosphorylated proteins like Syk and receptor tyrosine kinases. Dysregulation of PLCG2 is linked to immune disorders. Gain-of-function mutations are associated with autoinflammatory diseases (e.g., PLAID, APLAID), while loss-of-function variants may contribute to immunodeficiency.

PLCG2 antibodies are essential tools for studying its expression, activation, and localization in immune cells. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate its role in pathological mechanisms or therapeutic targeting. Research on PLCG2 antibodies also aids in developing diagnostic biomarkers and tailored therapies for immune-related conditions.

       
PLCG2抗体;PLCG2;PLCG2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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