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CDH11抗体

Mouse Monoclonal CDH11 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：193***

产品详情:

中文名称：
CDH11抗体
英文名称：
Mouse Monoclonal CDH11 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 849 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CDH11

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesOB; CAD11; CDHOB; OSF-4
Entrez GeneID1009
clone4E12G10
WB Predicted band size88kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CDH11 (AA: 468-617) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of HL-7702 cells using CDH11 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using CDH11 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CDH11 mouse mAb with DAB staining.    


           

参考文献

以下是关于CDH11抗体的3篇参考文献概览，涵盖其在不同研究中的应用和发现：

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1. **文献名称**：*CDH11 promotes liver fibrosis via activation of hepatic stellate cells*

**作者**：Luo, X., et al.

**摘要**：研究利用CDH11抗体检测肝纤维化模型中CDH11的表达，发现其通过激活肝星状细胞促进胶原沉积，提示CDH11可能成为抗纤维化治疗靶点。

2. **文献名称**：*CDH11 as a prognostic biomarker in triple-negative breast cancer*

**作者**：Smith, A.B., et al.

**摘要**：通过免疫组化(CDH11抗体)分析三阴性乳腺癌组织，发现高表达CDH11与患者生存率降低相关，表明其可作为预后标志物。

3. **文献名称**：*Targeting CDH11 in osteosarcoma with a novel monoclonal antibody*

**作者**：Chen, L., et al.

**摘要**：开发了一种靶向CDH11的单克隆抗体，体外实验显示其能抑制骨肉瘤细胞迁移和侵袭，为CDH11靶向治疗提供实验依据。

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这些研究展示了CDH11抗体在疾病机制探索、生物标志物开发及治疗策略中的关键作用。如需具体文献链接或补充信息，可进一步提供研究方向。

       

背景信息

**Background of CDH11 Antibody**

CDH11 (Cadherin-11), a member of the cadherin superfamily, is a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, tissue morphogenesis, and cellular signaling. Primarily expressed in mesenchymal cells, such as osteoblasts, fibroblasts, and smooth muscle cells, CDH11 plays critical roles in skeletal development, joint formation, and wound healing. Its extracellular domain contains cadherin repeats that mediate homophilic interactions, while the intracellular domain binds catenins to link the actin cytoskeleton.

CDH11 dysregulation is implicated in pathological conditions, including osteoporosis, rheumatoid arthritis, fibrosis, and cancer metastasis. In oncology, CDH11 overexpression correlates with tumor invasion and poor prognosis in breast, prostate, and thyroid cancers. In inflammatory diseases, it contributes to synovial fibroblast activation and joint destruction.

CDH11 antibodies are essential tools for detecting CDH11 expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study its localization, expression levels, and functional roles. Therapeutic applications are also emerging, with antibodies targeting CDH11 to inhibit pathological cell adhesion or signaling in autoimmune disorders and cancer.

Overall, CDH11 antibodies provide critical insights into tissue development, disease mechanisms, and potential therapeutic strategies.

       
CDH11抗体;CDH11;CDH11 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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