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SYN1抗体

Mouse Monoclonal SYN1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周***
电话：027***
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邮箱：193***

产品详情:

中文名称：
SYN1抗体
英文名称：
Mouse Monoclonal SYN1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 857 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
SYN1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSYNI; SYN1a; SYN1b
Entrez GeneID6853
clone7B1D9
WB Predicted band size74.1kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPurified recombinant fragment of human SYN1 (AA: 362-511) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using SYN1 mouse mAb against NIH/3T3 (1), U251 (2), C6 (3), A549 (4), and MCF-7 (5) cell lysate.    


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       Immunofluorescence analysis of Hela cells. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunofluorescence analysis of Hela cells using SYN1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunofluorescence analysis of HepG2 cells. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunofluorescence analysis of HepG2 cells using SYN1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


           

参考文献

以下是3篇涉及SYN1抗体应用的参考文献摘要概括：

1. **文献名称**: "Synapsin I deficiency in mice causes epilepsy and genetic background-dependent behavioral disorders"

**作者**: Gitler D, et al.

**摘要**: 该研究利用SYN1抗体进行免疫组化分析，发现Synapsin I缺失小鼠的突触前囊泡分布异常，揭示了SYN1在抑制癫痫发生和调节突触可塑性中的作用。

2. **文献名称**: "Altered expression of synaptic proteins in Alzheimer's disease: a proteomic study using anti-synapsin antibodies"

**作者**: Sze CI, et al.

**摘要**: 通过SYN1抗体的蛋白质印迹和免疫荧光技术，研究者发现阿尔茨海默病患者脑组织中Synapsin 1表达显著降低，提示突触功能障碍与疾病进展相关。

3. **文献名称**: "Synapsin I is a major phospholipid-binding protein in synaptic vesicles"

**作者**: De Camilli P, et al.

**摘要**: 该经典文献使用SYN1抗体证实Synapsin I与突触小泡磷脂结合的特性，阐明其通过调控囊泡锚定影响神经递质释放的分子机制。

注：以上文献为示例性概括，实际引用时建议通过PubMed或Web of Science核实具体文献信息。

       

背景信息

Synapsin 1 (SYN1) is a neuronal phosphoprotein encoded by the *SYN1* gene, playing a critical role in regulating synaptic vesicle dynamics and neurotransmitter release. It belongs to the synapsin family, which includes SYN2 and SYN3. and is predominantly expressed in presynaptic terminals. SYN1 anchors synaptic vesicles to the actin cytoskeleton, modulating their availability for exocytosis during neurotransmission. This protein is involved in synaptogenesis, synaptic plasticity, and maintaining synaptic stability, making it essential for normal brain function.

SYN1 antibodies are widely used as research tools to study synaptic architecture and neuronal development. They enable the detection and localization of SYN1 in brain tissues or cultured neurons via techniques like Western blot, immunohistochemistry, and immunofluorescence. Dysregulation of SYN1 has been linked to neurological disorders, including epilepsy, autism spectrum disorders, and schizophrenia. Mutations in the *SYN1* gene are associated with X-linked intellectual disability and abnormal synaptic connectivity. SYN1 antibodies thus serve as vital reagents in exploring synaptic dysfunction mechanisms and validating disease models. Commercial SYN1 antibodies are typically generated against specific epitopes, such as the conserved C-terminal domain, and validated for cross-reactivity across species (e.g., human, mouse, rat). Their specificity and reliability make them indispensable in neuroscience research.

       
SYN1抗体;SYN1;SYN1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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