VARS1抗体 新品

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Ramos cell lysate, Primary antibody: P03601(VARS1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P03601(VARS1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

VARS1 antibodies target valyl-tRNA synthetase (VARS1), an enzyme critical for protein synthesis. As a member of the aminoacyl-tRNA synthetase (ARS) family, VARS1 catalyzes the attachment of valine to its cognate tRNA, ensuring accurate translation of genetic codes into proteins. Unlike some cytosolic ARS enzymes, VARS1 localizes to mitochondria, reflecting its specialized role in mitochondrial translation and energy production.

Mutations in the *VARS1* gene are linked to mitochondrial disorders, including neurodevelopmental impairments, encephalopathy, and multisystemic dysfunction. VARS1 antibodies are essential tools in research to study these pathologies, enabling detection of protein expression, subcellular localization, and interactions. They are used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore VARS1’s role in mitochondrial health and disease mechanisms.

Clinically, VARS1 antibodies may aid in diagnosing genetic disorders by identifying aberrant protein levels or mutations. Additionally, autoantibodies against VARS1 (part of anti-synthetase syndrome) are associated with autoimmune conditions like dermatomyositis, though this differs from research-grade antibodies targeting the enzyme itself. Understanding VARS1’s structure-function relationships and dysregulation continues to inform therapeutic strategies for mitochondrial and autoimmune diseases.