ZFYVE16 抗体

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P03691(ZFYVE16 ? Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03691(ZFYVE16   Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The ZFYVE16 antibody is a tool used to detect and study the ZFYVE16 protein, also known as endofin or FYVE domain-containing protein 16. ZFYVE16 belongs to the FYVE protein family, characterized by a conserved zinc-binding FYVE domain that binds phosphatidylinositol 3-phosphate (PI3P), enabling its localization to endosomal membranes. This protein plays roles in endosomal trafficking, autophagy, and TGF-β/BMP signaling by acting as a scaffold or adaptor. It interacts with components like Smad4 and Rab5. influencing signaling pathways linked to cell growth, differentiation, and apoptosis. Dysregulation of ZFYVE16 has been implicated in cancers, neurodegenerative disorders, and immune diseases.

The ZFYVE16 antibody is typically produced in hosts such as rabbits or mice, using immunogenic peptides derived from conserved regions of the human ZFYVE16 protein. It is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, subcellular localization, and interactions in cell lines or tissues. Researchers employ this antibody to explore ZFYVE16's involvement in disease mechanisms, particularly its role in modulating membrane dynamics and signal transduction. Commercial antibodies are often validated for specificity via knockout controls. Its applications span basic research in cell biology and translational studies aiming to uncover therapeutic targets.