ADGRA2抗体

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     Western blot analysis of Phospho-Histone H2A (S129)  expression in Saccharomyces cerevisiae treated with Methyl methanesulfonate.    

  
  

The ADGRA2 (Adhesion G Protein-Coupled Receptor A2) antibody is a tool used to study the expression and function of ADGRA2. a member of the adhesion G protein-coupled receptor (GPCR) family. ADGRA2. also known as GPR124. is a transmembrane receptor characterized by a large extracellular N-terminus containing adhesion-related domains, such as leucine-rich repeats and immunoglobulin-like motifs. It plays critical roles in vascular and neural development, particularly in blood-brain barrier formation, angiogenesis, and central nervous system (CNS) patterning. ADGRA2 interacts with Wnt signaling pathways, acting as a co-receptor for Wnt7 ligands to regulate β-catenin-dependent signaling, essential for endothelial cell function and tissue homeostasis.

The ADGRA2 antibody is widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating ADGRA2's involvement in diseases, including cancer, where its dysregulation is linked to tumor angiogenesis and metastasis, and cerebrovascular disorders. Studies also explore its role in neuroinflammatory conditions and developmental anomalies. Validated for specificity and sensitivity, the antibody enables spatial and temporal analysis of ADGRA2 in biological samples, contributing to mechanistic insights and potential therapeutic targeting. Ongoing research continues to uncover its physiological and pathological significance across diverse tissues.