MAPK8IP1抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P04985(MAPK8IP1 Antibody) at dilution 1/50, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

The MAPK8IP1 antibody is a tool used to detect and study the Mitogen-activated protein kinase 8-interacting protein 1 (MAPK8IP1), also known as JNK-interacting protein 1 (JIP-1). MAPK8IP1 is a scaffold protein critical for regulating the c-Jun N-terminal kinase (JNK) signaling pathway, which influences cellular processes like apoptosis, stress response, and differentiation. It contains JNK-binding domains (JBDs) that facilitate interactions with JNK kinases (e.g., MAPK8/9/10) and upstream components, enhancing signaling efficiency and specificity.

Antibodies targeting MAPK8IP1 are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to analyze its expression, subcellular localization, and interactions in various tissues. Research highlights its role in neuronal development, insulin secretion, and cancer progression. Dysregulation of MAPK8IP1 is linked to neurodegenerative disorders (e.g., Alzheimer’s disease), diabetes, and tumorigenesis.

These antibodies are essential for elucidating MAPK8IP1’s molecular mechanisms, including its involvement in organelle transport, stress-activated signaling cascades, and cross-talk with other pathways like Wnt/β-catenin. Commercial antibodies are typically validated for specificity via knockout controls or siRNA knockdown. Their applications span basic research and preclinical studies, aiding in biomarker discovery and therapeutic target validation.