TRIM35抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Hela cells, K562 cells, human fetal muscle tissue, A375 cells, hepg2 cells, Primary antibody: P05414(TRIM35 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05414(TRIM35 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of TRIM35 Antibody**

The TRIM35 (Tripartite Motif-containing 35) antibody is a research tool designed to detect and study the TRIM35 protein, a member of the TRIM family. TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains, which often confer E3 ubiquitin ligase activity, enabling them to regulate ubiquitination-dependent processes. TRIM35 is implicated in diverse cellular functions, including cell proliferation, apoptosis, antiviral responses, and immune regulation. Studies suggest its involvement in pathways like NF-κB signaling and Wnt/β-catenin signaling, with roles in both physiological and pathological contexts, such as cancer.

TRIM35 has been linked to tumorigenesis, showing dual roles as a tumor suppressor or promoter depending on the cancer type. For instance, it suppresses hepatocellular carcinoma by promoting apoptosis but may enhance aggressiveness in lung adenocarcinoma. The TRIM35 antibody is crucial for detecting protein expression, localization, and interactions in experimental models (e.g., Western blot, immunoprecipitation, immunofluorescence). Its applications extend to exploring TRIM35's regulatory mechanisms, post-translational modifications, and therapeutic potential.

Available as polyclonal or monoclonal variants, the antibody's specificity and validation (via knockout controls or peptide blocking) are essential to ensure reliable results. Ongoing research continues to unravel TRIM35's complex roles, making this antibody a valuable resource in molecular and cancer biology.