XKR7抗体

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     Western blot analysis of CD11b in Raw264.7 lysates using CD11b antibody.    

  
  

The XKR7 antibody is a research tool targeting the XK-related protein 7 (XKR7), a member of the XK family of transmembrane proteins. Initially identified through genomic studies, XKR7 is structurally characterized by multiple transmembrane domains and is implicated in phospholipid scrambling, a process critical for externalizing phosphatidylserine (PS) during apoptosis. This protein plays a role in cell membrane dynamics, potentially influencing apoptotic signaling, cell migration, and immune recognition of dying cells.

XKR7 has drawn attention in studies of cancer biology and neurodegenerative diseases. Dysregulation of PS exposure is linked to pathological conditions, including tumor immune evasion and aberrant neuronal cell death. Antibodies against XKR7 enable detection and functional analysis of the protein in vitro and in vivo, aiding investigations into its physiological and pathological roles. They are utilized in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess XKR7 expression patterns across tissues or disease models.

Recent studies suggest XKR7's involvement in tumor metastasis and neuroinflammation, highlighting its potential as a therapeutic target or biomarker. However, its precise mechanisms remain under exploration. The XKR7 antibody thus serves as a vital reagent for unraveling its contributions to cellular processes and disease pathways, supporting both basic research and drug development efforts.