ADAMTSL2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cell lysate, Primary antibody: P07779(ADAMTSL2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07779(ADAMTSL2 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07779(ADAMTSL2 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The ADAMTSL2 antibody is a tool used to detect ADAMTS-like protein 2 (ADAMTSL2), a secreted glycoprotein belonging to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) superfamily. Unlike canonical ADAMTS proteases, ADAMTSL2 lacks enzymatic activity but plays critical roles in extracellular matrix (ECM) organization and cellular signaling. It interacts with fibrillin-1. TGF-β, and other ECM components, influencing tissue integrity and development. Mutations in the ADAMTSL2 gene are linked to geleophysic dysplasia 2 and acromicric dysplasia, rare genetic disorders characterized by skeletal abnormalities, short stature, and connective tissue defects.

ADAMTSL2 antibodies are primarily utilized in research to study protein expression, localization, and function in tissues and cell cultures. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating ADAMTSL2's role in ECM homeostasis, its involvement in TGF-β signaling modulation, and its pathological contributions to fibrosis or developmental disorders. Commercial antibodies are typically raised against specific epitopes, such as conserved regions within its thrombospondin-type or cysteine-rich domains. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. As ADAMTSL2 gains attention in connective tissue biology, its antibodies remain vital for exploring therapeutic targets and diagnostic markers for related diseases.