ASB2抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08049(ASB2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08049(ASB2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ASB2 antibody is designed to target the Ankyrin repeat and SOCS box protein 2 (ASB2), a member of the ASB family characterized by conserved ankyrin repeat domains and a C-terminal SOCS box motif. ASB2 functions as a substrate-recognition component of E3 ubiquitin ligase complexes, playing a role in ubiquitination-mediated protein degradation, which regulates cellular processes like signal transduction, differentiation, and apoptosis. It exists in two major isoforms, ASB2α and ASB2β, derived from alternative splicing, with ASB2α predominantly expressed in hematopoietic tissues and ASB2β in skeletal muscle.

Research highlights ASB2's involvement in cancer progression, particularly in leukemia and solid tumors, where it modulates cell migration, invasion, and metastasis by targeting proteins such as vinculin for degradation. Its expression is also linked to TGF-β signaling and immune response regulation. The ASB2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and interaction partners. Understanding ASB2's role in disease mechanisms, especially its dual functions as a tumor suppressor or promoter depending on context, remains a key focus, making the antibody a valuable tool for both basic research and potential therapeutic development.