MIA2抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, human brain malignant glioma tissue, A172 cells, Primary antibody: P08185(MIA2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08185(MIA2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08185(MIA2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The MIA2 (Melanoma Inhibitory Activity 2) antibody is a tool used to detect the MIA2 protein, a member of the MIA/OTOR family of secreted proteins. MIA2. also known as TANGO (Transport and Golgi Organization)-like protein, is structurally similar to MIA1. sharing a conserved SH3 domain critical for protein-protein interactions. Primarily expressed in hepatocytes and intestinal epithelial cells, MIA2 plays a role in regulating protein trafficking and secretion, particularly in the Golgi apparatus. It interacts with components of the extracellular matrix (ECM), influencing cell adhesion and migration processes.

MIA2 has been implicated in liver homeostasis and metabolic functions, with studies linking its dysregulation to liver diseases such as fibrosis and hepatocellular carcinoma. Unlike MIA1. which is associated with melanoma progression, MIA2’s involvement in cancer remains less defined but is an emerging area of research. The MIA2 antibody is widely utilized in immunoassays (e.g., Western blot, immunohistochemistry) to study its expression patterns, subcellular localization, and disease-related alterations. Validated for specificity, this antibody aids in exploring MIA2’s functional roles and potential as a biomarker or therapeutic target in hepatic and gastrointestinal pathologies.