FASTKD2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, LoVo cells, HepG2 cells, Primary antibody: P08318(FASTKD2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08318(FASTKD2 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08318(FASTKD2 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The FASTKD2 (FAST kinase domains-containing protein 2) antibody is a tool used to detect and study the FASTKD2 protein, a mitochondrial matrix protein involved in RNA metabolism and apoptosis regulation. FASTKD2 is part of the FASTK family, which plays roles in mitochondrial RNA processing, including the maturation of 16S rRNA and the stability of mitochondrial transcripts. It is implicated in maintaining mitochondrial function and cellular energy homeostasis. Research has linked FASTKD2 mutations to mitochondrial encephalomyopathies and neurodegenerative disorders, highlighting its importance in neuronal and muscular health.

The antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess FASTKD2 expression levels, localization, and interactions in cell lines or tissues. Studies employing this antibody have explored its role in stress-induced apoptosis, mitochondrial dynamics, and diseases such as Parkinson’s disease and cancer. Commercial FASTKD2 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes with validation across multiple applications. Its utility extends to both basic research and clinical investigations, aiding in understanding mitochondrial dysfunction mechanisms and potential therapeutic targets. Proper validation using knockout controls is essential to ensure specificity in experimental settings.