FGFR1OP2抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08330(FGFR1OP2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08330(FGFR1OP2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The FGFR1OP2 (Fibroblast Growth Factor Receptor 1 Oncogene Partner 2) antibody is a tool used to study the FGFR1OP2 protein, encoded by the *FGFR1OP2* gene located on human chromosome 12q12. FGFR1OP2. also known as FOP2 or C12orf5. is implicated in cellular processes like cytoskeletal regulation, cilia formation, and possibly tumorigenesis. It interacts with FGFR1 and other proteins, influencing cell signaling, migration, and proliferation. Dysregulation of FGFR1OP2 has been linked to cancers (e.g., leukemia, breast cancer) and ciliopathies (e.g., Joubert syndrome).

The FGFR1OP2 antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables detection of FGFR1OP2 in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers use it to explore FGFR1OP2’s localization (e.g., centrosomes, cilia), expression levels in diseased vs. healthy tissues, and its role in molecular pathways. Commercial antibodies vary in clonality (monoclonal/polyoclonal), epitope specificity, and validation criteria (e.g., knockout validation).

Its applications span basic research (e.g., studying cilia dysfunction) and translational studies (e.g., cancer biomarker analysis). However, users must validate antibody specificity due to potential cross-reactivity with homologous proteins. Overall, the FGFR1OP2 antibody is critical for unraveling the protein’s biological significance and its potential as a therapeutic target.