PDIA4抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW264.7 and NIH/3T3 cell lysates, Primary antibody: P09937(PDIA4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09937(PDIA4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09937(PDIA4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The protein disulfide isomerase family A member 4 (PDIA4), also known as ERP72. is a member of the protein disulfide isomerase (PDI) family, which plays a critical role in endoplasmic reticulum (ER)-associated protein folding and quality control. PDIA4 facilitates the formation, isomerization, and reduction of disulfide bonds in nascent polypeptides, ensuring proper tertiary structure. Structurally, it contains thioredoxin-like domains with catalytic CXXC motifs, enabling redox activity. Unlike some PDIs, PDIA4 is primarily involved in ER stress responses, acting as a chaperone during unfolded protein response (UPR) activation to mitigate cellular stress.

Studies link PDIA4 to various pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. Overexpression of PDIA4 has been observed in tumors, where it may promote cell survival under hypoxic or chemotherapeutic stress. In neurodegenerative contexts, dysregulated PDIA4 is associated with protein misfolding aggregates, such as amyloid-β and α-synuclein.

PDIA4 antibodies are essential tools for detecting protein expression in research applications like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate PDIA4’s role in ER stress pathways, disease mechanisms, and potential therapeutic targeting. Recent investigations also explore its utility as a biomarker for disease progression or treatment response, emphasizing its dual functional and diagnostic relevance.