SLC16A8抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P12176(SLC16A8 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12176(SLC16A8 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

SLC16A8. also known as monocarboxylate transporter 3 (MCT3), is a member of the solute carrier family 16 (SLC16) that facilitates the proton-coupled transport of monocarboxylates, such as lactate, pyruvate, and ketone bodies, across cell membranes. Primarily expressed in the retinal pigment epithelium (RPE) of the eye, SLC16A8 plays a critical role in maintaining retinal metabolic homeostasis by regulating lactate efflux from RPE cells to the choroid. This process is essential for photoreceptor function and overall visual health. Dysregulation of SLC16A8 has been implicated in retinal pathologies, including age-related macular degeneration (AMD) and diabetic retinopathy.

Antibodies targeting SLC16A8 are vital tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies enable researchers to detect SLC16A8 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Given the structural homology among SLC16 family members, SLC16A8-specific antibodies must be rigorously validated to ensure selectivity and avoid cross-reactivity. Such antibodies have been instrumental in elucidating SLC16A8's role in RPE-photoreceptor metabolic coupling and its potential as a therapeutic target. Recent studies also explore its expression in non-ocular tissues, broadening its relevance in cancer and metabolic disorders. High-quality SLC16A8 antibodies remain crucial for advancing research into vision-related diseases and metabolic regulation.