ZNF281抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05564(ZNF281 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P05564(ZNF281 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

ZNF281 (Zinc Finger Protein 281) is a transcription factor belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. It plays a critical role in regulating gene expression by binding to specific DNA sequences via its C-terminal C2H2-type zinc finger domains. ZNF281 is involved in diverse cellular processes, including cell proliferation, differentiation, and apoptosis, and has been implicated in cancer progression, stem cell maintenance, and epithelial-mesenchymal transition (EMT). Studies highlight its interaction with key signaling pathways, such as Wnt/β-catenin and p53. where it modulates transcriptional programs influencing tumorigenesis and metastasis. In cancer contexts, ZNF281 often exhibits dual roles—acting as an oncogene or tumor suppressor depending on the tissue type—making it a focus of research in cancers like colorectal, breast, and pancreatic cancer.

Antibodies targeting ZNF281 are essential tools for investigating its expression, localization, and functional mechanisms. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Commercially available ZNF281 antibodies are typically validated for specificity against conserved epitopes, often in human or murine samples. Researchers use them to explore ZNF281's role in disease models, its regulation of target genes (e.g., MYC, CDKN1A), and its potential as a biomarker or therapeutic target. Reliable antibodies are critical for elucidating ZNF281's complex contributions to cellular homeostasis and pathology.