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  • MAFB抗体—艾普蒂
  • MAFB抗体—艾普蒂
  • MAFB抗体—艾普蒂

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MAFB抗体—艾普蒂

Rabbit Polyclonal MAFB Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

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产品详情:

中文名称：
MAFB抗体
英文名称：
Rabbit Polyclonal MAFB Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2921 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAFB

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesKRML; MCTO
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human MAFB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: HEPG2, Hela, SKOV3 and Jurkat cell lysates, Primary antibody: P05694(MAFB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 6 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P05694(MAFB Antibody) at dilution 1/30. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05694(MAFB Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于MAFB抗体的3篇参考文献示例(内容为虚构，仅供参考格式)：

1. **《MAFB expression in macrophage differentiation and function》**

- **作者**: Motoda L, et al.

- **摘要**: 研究通过MAFB特异性抗体分析其在巨噬细胞极化中的作用，发现MAFB高表达于M2型巨噬细胞，并调控IL-10等抗炎因子分泌，提示其在免疫调控中的关键地位。

2. **《MAFB as a diagnostic marker in multiple myeloma》**

- **作者**: Nishida K, et al.

- **摘要**: 利用MAFB抗体进行免疫组化及流式分析，证实MAFB在多发性骨髓瘤细胞中特异性高表达，可作为区分浆细胞疾病的新型生物标志物。

3. **《MAFB regulates epidermal barrier formation in skin development》**

- **作者**: Chihiro S, et al.

- **摘要**: 通过MAFB抗体染色发现，MAFB在皮肤角质形成细胞分化中调控紧密连接蛋白表达，缺失导致小鼠模型出现严重表皮屏障缺陷。

4. **《MAFB in rheumatoid arthritis synovial fibroblasts》**

- **作者**: Morita Y, et al.

- **摘要**: 研究采用MAFB抗体检测类风湿关节炎患者滑膜细胞，发现MAFB通过NF-κB通路促进炎症因子释放，为潜在治疗靶点。

(注：以上文献为示例，实际引用需查询真实数据库如PubMed。)

       

背景信息

The MAFB antibody is a crucial tool in biomedical research, targeting the MAFB transcription factor, a member of the large Maf protein family. MAFB (v-maf musculoaponeurotic fibrosarcoma oncogene homolog B) contains a basic leucine zipper (bZIP) domain, enabling DNA binding and dimerization to regulate gene expression. It plays pivotal roles in cell differentiation, development, and homeostasis, particularly in macrophages, osteoclasts, pancreatic β-cells, and kidney podocytes.

MAFB is implicated in diseases such as multiple myeloma (where its overexpression drives oncogenesis), diabetes (linked to β-cell dysfunction), and renal disorders. Researchers use MAFB antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and dynamics in tissues or cultured cells. These antibodies aid in studying MAFB's regulatory mechanisms in immune responses, bone remodeling, and metabolic pathways.

Commercial MAFB antibodies are typically validated for specificity across human, mouse, and rat samples. However, cross-reactivity with other Maf proteins (e.g., MAFA, c-MAF) requires careful validation via knockout controls. Recent studies also explore MAFB's role in cancer metastasis and autoimmune diseases, expanding its therapeutic relevance. Overall, MAFB antibodies remain indispensable for unraveling its biological functions and pathological contributions.

       
MAFB抗体;MAFB;MAFB Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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