URB1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06037(URB1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06037(URB1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The URB1 (U3 snoRNA-associated ribonucleoprotein 1) antibody is a tool used to study the URB1 protein, a key component of the U3 small nucleolar ribonucleoprotein (snoRNP) complex. URB1 plays a critical role in ribosomal RNA (rRNA) processing, particularly during the cleavage and modification of 18S rRNA, a step essential for ribosome biogenesis. This protein is localized to the nucleolus, where it facilitates the assembly and maturation of ribosomal subunits, linking ribosome synthesis to cell proliferation and growth regulation.

URB1 antibodies are widely employed in molecular biology research to detect URB1 expression levels, subcellular localization, and interactions via techniques like Western blotting (WB), immunofluorescence (IF), and immunoprecipitation (IP). Studies have implicated URB1 dysregulation in pathological conditions, including cancer, where its overexpression correlates with tumor progression in colorectal, liver, and other cancers. Additionally, URB1 mutations or deficiencies are associated with developmental disorders, highlighting its role in cellular homeostasis.

As a research reagent, URB1 antibodies help elucidate mechanisms of ribosomopathies, cancer biology, and cell cycle control. They also serve as potential biomarkers for diagnostic or therapeutic targeting. Commercial URB1 antibodies are typically validated for specificity in human or model organisms, with applications spanning basic research and translational studies.