BASP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P06053(BASP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06053(BASP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

BASP1 (Brain Acid Soluble Protein 1), also known as CAP-23 or NAP-22. is a membrane-associated protein predominantly expressed in neuronal tissues, though it is also detected in other cell types. It plays roles in neuronal plasticity, axonal regeneration, and cellular signaling by modulating membrane-cytoskeleton interactions. BASP1 contains a conserved N-terminal myristoylation site for membrane anchoring and a C-terminal intrinsically disordered region involved in protein interactions. Its function is linked to lipid raft domains, where it influences signal transduction pathways, including the Wnt/β-catenin and growth factor-mediated signaling.

BASP1 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate BASP1's role in neurodevelopment, synaptic plasticity, and cancer. Notably, BASP1 is implicated in tumor suppression, with reduced expression observed in certain cancers, making it a potential biomarker. Antibodies targeting specific epitopes (e.g., phosphorylated residues) help dissect post-translational modifications regulating its activity. Commercially available BASP1 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat samples. Recent studies also explore BASP1's involvement in epigenetic regulation through interactions with transcriptional complexes, expanding its relevance beyond neuronal contexts.