CORO1A抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P06223(CORO1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06223(CORO1A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

CORO1A (Coronin 1A) is a member of the coronin protein family, which plays critical roles in regulating actin cytoskeleton dynamics, immune cell function, and intracellular signaling. Encoded by the *CORO1A* gene, this protein is predominantly expressed in immune cells, particularly T lymphocytes, neutrophils, and macrophages. It facilitates cell migration, phagocytosis, and T-cell receptor signaling by interacting with actin filaments and modulating their polymerization or stabilization. CORO1A also participates in calcium-dependent pathways and vesicle trafficking, influencing immune responses and inflammation.

Mutations in *CORO1A* are linked to severe immunodeficiency disorders, such as autosomal recessive severe combined immunodeficiency (SCID), characterized by impaired T-cell development and function. This association underscores its essential role in immune system regulation.

CORO1A antibodies are vital tools in biomedical research, enabling the detection and quantification of CORO1A protein in techniques like Western blotting, immunofluorescence, and flow cytometry. These antibodies help investigate CORO1A’s involvement in immune pathologies, cancer metastasis (due to its role in cell motility), and autoimmune diseases. Commercially available CORO1A antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes with validated specificity for human, mouse, or rat samples. Their applications extend to studying molecular mechanisms of immune dysregulation and evaluating therapeutic targets in preclinical models.