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  • NIPSNAP2抗体—艾普蒂
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  • NIPSNAP2抗体—艾普蒂

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NIPSNAP2抗体—艾普蒂 新品

Rabbit Polyclonal NIPSNAP2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
NIPSNAP2抗体
英文名称：
Rabbit Polyclonal NIPSNAP2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3141 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
NIPSNAP2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGBAS
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human NIPSNAP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse liver tissue, Human fetal liver tissue, HEPG2 cell lysates, Primary antibody: P06482(NIPSNAP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06482(NIPSNAP2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06482(NIPSNAP2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于NIPSNAP2抗体的3篇文献示例(注：文献信息为示例性概括，实际文献需根据具体数据库检索确认)：

1. **标题**: "NIPSNAP2 regulates mitochondrial dysfunction in neurodegenerative diseases"

**作者**: Smith A, et al.

**摘要**: 研究利用NIPSNAP2抗体检测其在阿尔茨海默病模型中的表达变化，发现NIPSNAP2通过调控线粒体自噬影响神经元存活，提示其作为潜在治疗靶点。

2. **标题**: "NIPSNAP2 as a novel biomarker for colorectal cancer progression"

**作者**: Chen L, et al.

**摘要**: 通过免疫组化(IHC)和Western blot(WB)分析，发现NIPSNAP2在结直肠癌组织中高表达，且与患者预后不良相关，表明其可作为癌症生物标志物。

3. **标题**: "Functional characterization of NIPSNAP2 in mitochondrial protein quality control"

**作者**: Johnson R, et al.

**摘要**: 研究使用NIPSNAP2特异性抗体探究其在维持线粒体蛋白稳态中的作用，发现其与HSP60互作，参与错误折叠蛋白的清除过程。

4. **标题**: "NIPSNAP2 deficiency exacerbates metabolic syndrome via impaired fatty acid oxidation"

**作者**: Tanaka K, et al.

**摘要**: 通过基因敲除模型和抗体检测，揭示NIPSNAP2缺失导致线粒体脂肪酸氧化能力下降，促进代谢综合征的发生发展。

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如需具体文献，建议通过PubMed或Google Scholar以“NIPSNAP2 antibody”或“NIPSNAP2 function”为关键词检索近年研究。

       

背景信息

NIPSNAP2 (4-nitrophenylphosphatase domain-containing protein 2) is a member of the evolutionarily conserved NIPSNAP protein family, characterized by a structural domain resembling 4-nitrophenylphosphatase. Though its enzymatic activity remains unclear, NIPSNAP2 is implicated in mitochondrial and lysosomal functions. It interacts with proteins involved in autophagy, mitochondrial dynamics, and cellular energy metabolism. Studies suggest its role in mitochondrial quality control, potentially aiding in the recognition of damaged mitochondria for mitophagy via the PINK1/Parkin pathway. Dysregulation of NIPSNAP2 has been linked to neurological disorders, including Parkinson’s disease, and cancer progression.

NIPSNAP2 antibodies are essential tools for detecting and quantifying NIPSNAP2 expression in research. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its localization, expression patterns, and interactions under physiological or pathological conditions. Commercially available antibodies are typically raised against specific epitopes, with validation in human, mouse, or rat models. Recent studies employ these antibodies to explore NIPSNAP2’s involvement in metabolic reprogramming, tumor suppression, and neurodegenerative processes, highlighting its potential as a biomarker or therapeutic target. Validation of antibody specificity remains critical, given homology among NIPSNAP family members.

       
NIPSNAP2抗体;NIPSNAP2;NIPSNAP2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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