GLUD1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue and Rat liver tissue lysates, Primary antibody: P06573(GLUD1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06573(GLUD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The glutamate dehydrogenase 1 (GLUD1) antibody is a crucial tool in biomedical research for studying the function and expression of GLUD1. a mitochondrial enzyme encoded by the GLUD1 gene. GLUD1 catalyzes the reversible conversion of glutamate to α-ketoglutarate, linking amino acid metabolism to the tricarboxylic acid (TCA) cycle and playing a pivotal role in cellular energy production, nitrogen disposal, and neurotransmitter synthesis. Dysregulation of GLUD1 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making it a target for diagnostic and therapeutic investigations.

GLUD1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, subcellular localization, and tissue distribution. They are particularly valuable in studying hyperinsulinism-hyperammonemia syndrome (HI/HA), a rare genetic disorder caused by gain-of-function GLUD1 mutations that lead to excessive insulin secretion. In cancer research, GLUD1 antibodies help explore metabolic reprogramming in tumors, as many cancers exhibit altered GLUD1 expression to support rapid proliferation. Additionally, these antibodies aid in investigating GLUD1's role in neurological conditions, such as Parkinson’s and Alzheimer’s diseases, where glutamate metabolism imbalances may contribute to pathology.

Most GLUD1 antibodies are raised against specific epitopes of the human GLUD1 protein and are available as monoclonal or polyclonal variants from commercial suppliers. Their applications span basic research, clinical diagnostics, and drug development, underscoring their importance in understanding cellular metabolism and disease mechanisms.