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  • PEMT抗体—艾普蒂
  • PEMT抗体—艾普蒂
  • PEMT抗体—艾普蒂

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PEMT抗体—艾普蒂

Rabbit Polyclonal PEMT Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-18

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
PEMT抗体
英文名称：
Rabbit Polyclonal PEMT Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 3260 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PEMT

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPLMT; PNMT; PEAMT; PEMPT; PEMT2
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PEMT
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Mouse liver tissue, HepG2, 293T and 231 cell lysates, Primary antibody: P06778(PEMT Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06778(PEMT Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06778(PEMT Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是3篇与PEMT(磷脂酰乙醇胺N-甲基转移酶)抗体相关的文献摘要信息：

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1. **文献名称**: *Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice are protected from diet-induced obesity and hepatic steatosis*

**作者**: Jacobs RL et al.

**摘要**: 该研究利用PEMT基因敲除小鼠模型，通过Western blot和免疫组化技术(使用特异性PEMT抗体)证明PEMT缺失可减少高脂饮食诱导的肝脏脂肪堆积和胰岛素抵抗，提示PEMT在脂代谢调控中的关键作用。

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2. **文献名称**: *Regulation of hepatic phosphatidylethanolamine N-methyltransferase by sphingomyelin synthase 2*

**作者**: Walkey CJ et al.

**摘要**: 研究通过免疫沉淀(使用PEMT多克隆抗体)发现鞘磷脂合酶2(SMS2)通过直接相互作用调控PEMT酶活性，揭示了二者在维持细胞膜磷脂平衡中的协同机制。

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3. **文献名称**: *Membrane-binding and enzymatic properties of phosphatidylethanolamine N-methyltransferase*

**作者**: Resh MD, Vance DE

**摘要**: 文章利用抗PEMT抗体进行亚细胞定位分析，证实PEMT通过C端疏水结构域锚定于内质网膜，并解析其催化磷脂酰乙醇胺转化为磷脂酰胆碱的分子机制。

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**注**：实际文献引用需核对具体卷号、页码及发表年份。若需扩展，可补充PEMT抗体在肿瘤或神经疾病中的研究(如Shields et al. 2021对PEMT与钙调蛋白相互作用的研究)。

       

背景信息

Phosphatidylethanolamine N-methyltransferase (PEMT) is a key enzyme in phospholipid metabolism, primarily expressed in the liver. It catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC), a critical process for maintaining membrane integrity and lipid homeostasis. PEMT-derived PC is essential for very-low-density lipoprotein (VLDL) secretion and contributes to hepatic lipid balance. Dysregulation of PEMT activity has been implicated in metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), insulin resistance, and cardiovascular diseases.

PEMT antibodies are immunological tools developed to detect and quantify PEMT protein levels in biological samples. These antibodies enable researchers to study PEMT's expression patterns, regulatory mechanisms, and its role in disease pathogenesis. Polyclonal and monoclonal variants are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies using PEMT antibodies have revealed tissue-specific expression profiles and sex-dependent differences in enzyme activity. Additionally, they have helped elucidate PEMT's compensatory role in PC synthesis when the CDP-choline pathway is impaired. Validated PEMT antibodies are crucial for investigating lipid metabolism pathways and developing therapeutic strategies targeting phospholipid-related metabolic disorders.

       
PEMT抗体;PEMT;PEMT Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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