RARB抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, human normal liver tissue, Primary antibody: P06947(RARB Antibody) at dilution 1/283, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

**Background of RARB Antibody**

The retinoic acid receptor beta (RARβ), encoded by the *RARB* gene, belongs to the nuclear receptor superfamily and functions as a ligand-dependent transcription factor. It plays a critical role in mediating the effects of retinoic acid (RA), a derivative of vitamin A involved in cell differentiation, proliferation, and apoptosis. RARβ binds to RA response elements in DNA, regulating target genes essential for embryonic development, tissue homeostasis, and immune response. Dysregulation of RARβ has been linked to various pathologies, including cancer (e.g., breast, lung, and prostate), psoriasis, and pulmonary fibrosis, often due to epigenetic silencing or loss of heterozygosity.

RARB antibodies are immunological tools designed to detect and quantify RARβ protein expression in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study RARβ's tissue distribution, subcellular localization, and expression levels under physiological or pathological conditions. They are particularly valuable in cancer research, where RARβ is investigated as a potential tumor suppressor or biomarker for therapeutic response. Commercial RARB antibodies are typically validated for specificity against epitopes in the ligand-binding or DNA-binding domains, ensuring accurate detection across human and model organism samples.