MAT1A抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P06956(MAT1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

MAT1A (Methionine Adenosyltransferase 1A) is a crucial enzyme encoded by the MAT1A gene, primarily expressed in the liver. It catalyzes the synthesis of S-adenosylmethionine (SAMe), the principal methyl donor in numerous biological processes, including methylation of DNA, proteins, and lipids. MAT1A plays a pivotal role in maintaining hepatic function, regulating oxidative stress, and influencing cell proliferation. Dysregulation of MAT1A is linked to liver diseases (e.g., cirrhosis, hepatocellular carcinoma), metabolic disorders, and certain cancers, underscoring its importance in cellular homeostasis.

MAT1A antibodies are immunological tools designed to detect and quantify MAT1A protein expression in research applications. These antibodies, often developed in rabbit or mouse hosts, are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is ensured through epitope mapping or knockout validation. Researchers use MAT1A antibodies to investigate its expression patterns in disease models, study SAMe-related metabolic pathways, or explore therapeutic targets. Commercial MAT1A antibodies typically include detailed datasheets outlining cross-reactivity, recommended dilutions, and storage conditions. Reliable MAT1A antibodies are critical for advancing studies on liver pathophysiology, epigenetics, and cancer metabolism.