COX16抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07018(COX16 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07018(COX16 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

COX16 (Cytochrome c oxidase assembly protein 16) is a nuclear-encoded mitochondrial protein critical for the biogenesis of the cytochrome c oxidase (COX) complex, the terminal enzyme in the mitochondrial electron transport chain. Discovered through studies of yeast homologs, human COX16 is localized to the mitochondrial inner membrane and facilitates the assembly of COX subunits, particularly stabilizing the maturation of the catalytic core subunit COX2. It interacts with other assembly factors, such as COX14 and COA3. to coordinate copper insertion into the COX1 and COX2 subunits, a vital step for enzymatic activity.

COX16 antibodies are essential tools for investigating mitochondrial respiratory chain disorders and metabolic diseases linked to COX dysfunction. These antibodies enable the detection and quantification of COX16 protein levels in tissues or cultured cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use them to study COX16's role in cellular energy production, its tissue-specific expression patterns, and its involvement in pathologies such as neurodegenerative diseases, cardiomyopathies, and Leigh syndrome. Commercially available COX16 antibodies are typically raised in rabbits or mice using peptide antigens corresponding to conserved regions of the protein. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity. Understanding COX16's function through antibody-based research provides insights into mitochondrial biology and potential therapeutic targets for oxidative phosphorylation deficiencies.