AARS2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: SP20 cells, Primary antibody: P07061(AARS2 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07061(AARS2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07061(AARS2 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The alanyl-tRNA synthetase 2 (AARS2) antibody is a research tool designed to detect and study the AARS2 protein, a mitochondrial aminoacyl-tRNA synthetase critical for protein synthesis within mitochondria. AARS2 catalyzes the attachment of alanine to its cognate tRNA, ensuring the accuracy of mitochondrial translation. Mutations in the AARS2 gene are linked to human diseases, including progressive mitochondrial encephalopathy, hypertrophic cardiomyopathy, and ovarian failure, highlighting its role in mitochondrial function and cellular energy metabolism.

AARS2 antibodies are widely used in biomedical research to investigate mitochondrial disorders and their molecular mechanisms. They enable the detection of AARS2 expression levels, subcellular localization (primarily in mitochondria), and post-translational modifications through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in studying tissue-specific expression patterns, particularly in energy-demanding organs such as the heart, brain, and liver. Additionally, they are valuable for exploring how AARS2 dysfunction contributes to disease pathogenesis, offering insights into potential therapeutic targets. Commercial AARS2 antibodies are typically validated for specificity and sensitivity, often using knockout controls to ensure reliability in experimental models.