PIDD1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08484(PIDD1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08484(PIDD1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PIDD1 antibody is a crucial tool for studying the p53-induced death domain protein 1 (PIDD1), a multifunctional protein encoded by the *PIDD1* gene. PIDD1 plays a pivotal role in cellular stress responses, particularly in DNA damage repair, cell cycle regulation, and apoptosis. It is activated by genotoxic stress and interacts with components of the PIDDosome complex, which modulates caspase-2 activation and NF-κB signaling, influencing cell fate decisions between survival and death. PIDD1’s dual roles in pro-apoptotic and pro-survival pathways make it significant in cancer research, neurodegenerative diseases, and genome stability studies.

Antibodies targeting PIDD1 enable detection and quantification of the protein in techniques like Western blot, immunohistochemistry, and immunofluorescence. They are essential for exploring PIDD1 expression patterns across tissues, its subcellular localization, and interactions with binding partners (e.g., RAIDD, RIPK1). Commercially available PIDD1 antibodies are often validated using knockout cell lines or recombinant proteins to ensure specificity, given the presence of multiple PIDD1 isoforms. Researchers rely on these antibodies to dissect PIDD1’s context-dependent functions, particularly its interplay with p53 and implications in tumorigenesis or chemotherapy resistance. Understanding PIDD1 dynamics through antibody-based assays continues to advance insights into cellular stress adaptation mechanisms.