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  • MAGEA8抗体—艾普蒂
  • MAGEA8抗体—艾普蒂
  • MAGEA8抗体—艾普蒂

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MAGEA8抗体—艾普蒂

Rabbit Polyclonal MAGEA8 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
MAGEA8抗体
英文名称：
Rabbit Polyclonal MAGEA8 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4173 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAGEA8

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCT1.8; MAGE8
WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human MAGEA8
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P08493(MAGEA8 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08493(MAGEA8 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08493(MAGEA8 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEA8抗体的示例性参考文献(内容为模拟概括，建议通过学术数据库核实最新文献)：

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1. **标题**: *MAGEA8 as a novel biomarker in lung adenocarcinoma detected by monoclonal antibody*

**作者**: Zhang L, et al.

**摘要**: 研究开发了针对MAGEA8的单克隆抗体，证实其在肺腺癌组织中高表达，而在正常组织中几乎无表达。抗体通过免疫组化验证，可能作为肺癌诊断的潜在标志物。

2. **标题**: *Therapeutic potential of anti-MAGEA8 antibody in melanoma models*

**作者**: Smith J, et al.

**摘要**: 研究利用抗MAGEA8抗体在小鼠黑色素瘤模型中诱导抗体依赖性细胞毒性(ADCC)，显示肿瘤生长抑制，提示其作为免疫治疗靶点的可行性。

3. **标题**: *MAGEA8 antibody reveals differential expression in germ cell tumors*

**作者**: Tanaka K, et al.

**摘要**: 通过抗MAGEA8抗体分析生殖细胞肿瘤样本，发现其在精原细胞瘤中高表达，与临床分期相关，可能用于病理分型和预后评估。

4. **标题**: *Epitope mapping of MAGEA8-specific antibodies for T-cell activation*

**作者**: Müller R, et al.

**摘要**: 研究定位了MAGEA8抗体识别的抗原表位，并证明其可增强T细胞对肿瘤细胞的识别，为个性化疫苗设计提供理论基础。

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**注意**：以上文献信息为模拟生成，实际研究中请通过PubMed、Web of Science等平台以“MAGEA8 antibody”为关键词检索最新论文。真实研究多集中于MAGEA家族(如MAGEA3/4)，针对MAGEA8的抗体文献相对较少，建议扩展检索范围。

       

背景信息

The melanoma-associated antigen A8 (MAGEA8) is a member of the MAGE family of cancer-testis antigens (CTAs), which are primarily expressed in germline cells and aberrantly reactivated in various cancers. Located on the X chromosome, MAGEA8 encodes a protein with a conserved MAGE homology domain, though its precise biological function remains unclear. Like other CTAs, MAGEA8 is normally silenced in somatic tissues due to promoter hypermethylation but becomes re-expressed in malignancies such as melanoma, lung cancer, and hepatocellular carcinoma, where it may contribute to tumorigenesis, immune evasion, or therapy resistance.

Antibodies targeting MAGEA8 are critical tools for studying its expression patterns, functional roles, and potential as a diagnostic or therapeutic biomarker. These antibodies enable detection via techniques like immunohistochemistry (IHC), Western blotting, or ELISA, aiding in correlating MAGEA8 levels with cancer progression or prognosis. Additionally, MAGEA8-specific antibodies are explored in immunotherapy contexts, such as chimeric antigen receptor (CAR) T-cell therapies or antibody-drug conjugates (ADCs), leveraging its tumor-restricted expression to minimize off-target effects.

However, challenges persist, including variable MAGEA8 expression across tumors, cross-reactivity with other MAGE proteins, and limited understanding of its interaction networks. Ongoing research aims to refine antibody specificity and evaluate clinical utility in personalized oncology approaches.

       
MAGEA8抗体;MAGEA8;MAGEA8 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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