ZMAT3抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08593(ZMAT3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08593(ZMAT3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

ZMAT3. also known as PAG608 or WIG1. is a zinc finger-containing protein encoded by the p53-regulated gene ZMAT3. It plays a role in cellular stress responses, apoptosis, and tumor suppression, primarily through its interaction with RNA and modulation of RNA stability or splicing. As a downstream target of the tumor suppressor p53. ZMAT3 is involved in mediating p53-dependent growth arrest and apoptosis, making it a key player in cancer biology and cellular homeostasis.

ZMAT3 antibodies are essential tools for studying the expression, localization, and function of this protein in various biological contexts. These antibodies are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous ZMAT3 levels in cell lines, tissues, or experimental models. Researchers employ ZMAT3 antibodies to investigate its role in p53 signaling, cancer progression, and responses to DNA damage or chemotherapeutic agents.

Commercial ZMAT3 antibodies are typically developed in hosts like rabbits or mice, with validation across multiple applications and species (e.g., human, mouse). Specificity and sensitivity are critical, as ZMAT3 shares structural motifs with other zinc finger proteins. Proper validation using knockout controls or siRNA-mediated knockdown is recommended. Studies leveraging these antibodies have highlighted ZMAT3's dual role in tumor suppression and oncogenesis, depending on cellular context, underscoring its therapeutic and diagnostic potential.