PHLPP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03786(FGF4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03786(FGF4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

PHLPP1 (Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase 1) is a serine/threonine phosphatase that plays a critical role in regulating cellular signaling pathways, particularly the PI3K/Akt and Ras/Raf/MEK/ERK cascades. It functions as a tumor suppressor by dephosphorylating and inactivating key kinases like Akt and PKC, thereby modulating cell survival, proliferation, and apoptosis. Dysregulation of PHLPP1 has been implicated in cancer, neurodegenerative disorders, and metabolic diseases, with its downregulation often linked to poor prognosis and therapy resistance.

Antibodies targeting PHLPP1 are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate PHLPP1's role in health and disease. Researchers utilize them to assess tissue-specific expression patterns, monitor post-translational modifications, or evaluate correlations between PHLPP1 levels and clinical outcomes. Due to structural similarities between PHLPP1 and its isoform PHLPP2. antibody specificity is rigorously validated to avoid cross-reactivity. Recent studies also employ PHLPP1 antibodies in therapeutic exploration, such as identifying biomarkers or developing strategies to restore PHLPP1 function in cancers. Proper validation using knockout controls or siRNA-mediated silencing remains critical for experimental accuracy.