RBM5抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-6: 823 cells, A549 cells, K562 cells, 293T cells, hepg2 cells, huvec cells, Primary antibody: P08682(RBM5 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08682(RBM5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08682(RBM5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RNA-binding motif protein 5 (RBM5) is a member of the RNA-binding protein family, known for its role in post-transcriptional gene regulation, particularly in mRNA splicing, stability, and translation. RBM5 contains conserved RNA recognition motifs (RRMs) and a zinc finger domain, enabling interactions with RNA and protein partners. It is implicated in critical cellular processes, including cell cycle control, apoptosis, and differentiation. Research highlights its tumor-suppressive functions, as RBM5 expression is frequently downregulated in cancers such as lung, breast, and prostate cancer. It modulates alternative splicing of apoptosis-related genes (e.g., Bcl-x, FAS) and regulates signaling pathways like the p53 and MAPK cascades, influencing cancer progression and therapy resistance.

RBM5 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate RBM5's role in normal physiology and disease. Commercially available antibodies target specific epitopes within its N-terminal or C-terminal regions, with validation across human and model organism tissues. Dysregulation of RBM5 has also been linked to neurological disorders, expanding its research relevance. However, challenges remain in understanding its isoform-specific functions and regulatory networks. Ongoing studies aim to clarify RBM5's potential as a diagnostic biomarker or therapeutic target, particularly in precision oncology.