DSTYK抗体—艾普蒂

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 823 cells, hepg2 cells, Primary antibody: P08705(DSTYK Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08705(DSTYK Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The DSTYK (dual serine/threonine and tyrosine protein kinase) antibody is a research tool used to detect and study the DSTYK protein, a member of the tyrosine kinase-like subfamily. DSTYK, also known as RIP5 or ROR3. is a transmembrane protein with dual kinase activity, capable of phosphorylating serine/threonine and tyrosine residues. It plays a regulatory role in cellular signaling pathways, including MAPK/ERK and PI3K/AKT, influencing processes like cell proliferation, differentiation, and apoptosis. DSTYK is implicated in organ development, particularly in the kidneys, and mutations in its gene are linked to congenital urinary tract malformations.

In disease contexts, DSTYK dysregulation is associated with cancers (e.g., renal cell carcinoma, colorectal cancer), metabolic disorders, and inflammatory conditions. The DSTYK antibody is essential for immunohistochemistry, Western blotting, and immunofluorescence to visualize protein expression, localization, and interactions in tissues or cell lines. It aids in exploring DSTYK's pathophysiological roles, potential as a biomarker, and therapeutic target. Validated antibodies ensure specificity, often confirmed via knockout controls, enabling reliable research into DSTYK's signaling mechanisms and clinical relevance.