SNAP47抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08790(SNAP47 Antibody) at dilution 1/200. (Original magnification: ×200)    

  
  

The SNAP47 antibody is a research tool designed to detect SNAP47 (Synaptosomal-associated protein 47), a member of the SNARE (soluble NSF attachment protein receptor) family involved in intracellular membrane fusion processes. SNAP47. encoded by the SNAP47 gene in humans, shares structural homology with other SNAP proteins like SNAP25 and SNAP29 but exhibits distinct localization and functional roles. It is broadly expressed across tissues and participates in diverse trafficking pathways, including endosomal sorting, autophagosome-lysosome fusion, and unconventional secretion. Unlike its homologs, SNAP47 localizes to both neuronal and non-neuronal compartments, suggesting versatility in membrane dynamics.

Researchers utilize SNAP47 antibodies primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its expression, interaction partners, and subcellular distribution. These antibodies are critical for exploring SNAP47’s role in cellular homeostasis, neurodegenerative diseases (e.g., Alzheimer’s), and cancer, where disrupted membrane trafficking is implicated. Commercial SNAP47 antibodies are often validated for specificity against recombinant proteins or knockout cell lines to minimize cross-reactivity with other SNAREs. Challenges include distinguishing isoforms and detecting low-abundance endogenous SNAP47 in certain cell types. Recent studies highlight its involvement in LC3-associated phagocytosis and mTOR signaling, underscoring its emerging importance in cell biology and therapeutic targeting.