UBL4B抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08937(UBL4B Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The UBL4B antibody is a research tool designed to detect ubiquitin-like protein 4B (UBL4B), a member of the ubiquitin-like protein family involved in diverse cellular processes. UBL4B, also known as GET4. plays a critical role in the guided entry of tail-anchored proteins (GET) pathway, which mediates the proper targeting and insertion of tail-anchored membrane proteins into the endoplasmic reticulum. This pathway is essential for maintaining cellular homeostasis, protein quality control, and organelle function. UBL4B interacts with other GET complex components, such as GET3 and GET5. to facilitate substrate recognition and trafficking.

Antibodies targeting UBL4B are typically developed in immunized hosts (e.g., rabbits or mice) using recombinant UBL4B protein fragments or synthetic peptides as antigens. These antibodies enable the detection and quantification of UBL4B expression in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers utilize UBL4B antibodies to explore its regulatory roles in cellular stress responses, cancer biology, and neurodegenerative diseases, where protein misfolding and trafficking defects are implicated.

Studies suggest UBL4B may also participate in autophagy and immune signaling, highlighting its broader functional relevance. Validated UBL4B antibodies are crucial for elucidating its molecular mechanisms and potential therapeutic applications. Specificity and cross-reactivity data are essential to ensure accurate experimental outcomes in diverse model systems.