ZFAND1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue, Mouse brain tissue lysates, Primary antibody: P09013(ZFAND1 Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09013(ZFAND1 Antibody) at dilution 1/95. (Original magnification: ×200)    

  
  

ZFAND1 (Zinc Finger AN1-type containing 1), also known as AWP1. is a protein encoded by the ZFAND1 gene in humans. It contains an N-terminal AN1-type zinc finger domain and a C-terminal ubiquitin-like (UBL) domain, which are critical for its role in protein-protein interactions and involvement in ubiquitin-related pathways. ZFAND1 is implicated in cellular stress response mechanisms, particularly under oxidative or endoplasmic reticulum (ER) stress, where it interacts with the ubiquitin-proteasome system to regulate protein quality control. Studies suggest it may act as a co-chaperone, aiding in the clearance of misfolded proteins by facilitating their ubiquitination and degradation.

ZFAND1 has been linked to diverse cellular processes, including apoptosis, autophagy, and inflammation. Its dysregulation is associated with diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. In cancer, ZFAND1 exhibits dual roles, functioning as a tumor suppressor in some contexts (e.g., inhibiting NF-κB signaling) or promoting metastasis in others, depending on tissue-specific interactions.

ZFAND1 antibodies are essential tools for studying these functions. They are used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect expression levels, subcellular localization, and interaction partners of ZFAND1. Validated antibodies typically target specific epitopes within the AN1 or UBL domains. Researchers prioritize antibodies with high specificity, often confirmed using ZFAND1-knockout controls. Commercial ZFAND1 antibodies are available in various host species (e.g., rabbit, mouse) and formats (monoclonal/polyoclonal), enabling broad experimental flexibility in both basic and clinical research.