ZFP64抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09017(ZFP64 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

ZFP64 antibody is a research tool designed to detect ZFP64 (Zinc Finger Protein 64), also known as ZNF259. a member of the zinc finger protein family. Zinc finger proteins are characterized by conserved cysteine and histidine residues that form structural motifs capable of binding DNA, RNA, or other proteins. ZFP64 is implicated in transcriptional regulation, though its precise biological roles remain under investigation. Studies suggest it may act as a transcriptional repressor or activator, depending on cellular context, and could play roles in development, differentiation, or oncogenesis.

The antibody is commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study ZFP64 expression and localization in tissues or cultured cells. Its applications extend to cancer research, as aberrant ZFP64 expression has been observed in certain malignancies. For example, ZFP64 has been linked to leukemia progression and solid tumor regulation through interactions with signaling pathways like NF-κB or Wnt.

Commercial ZFP64 antibodies are typically raised against specific epitopes, often in mice or rabbits, and require validation for species reactivity and assay compatibility. Researchers must optimize conditions (e.g., antigen retrieval, dilution ratios) to ensure specificity, as cross-reactivity with homologous zinc finger proteins can occur. Recent studies continue to explore ZFP64's functional diversity, making this antibody a critical reagent for elucidating its roles in gene networks and disease mechanisms.