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  • RUFY4抗体—艾普蒂
  • RUFY4抗体—艾普蒂
  • RUFY4抗体—艾普蒂

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RUFY4抗体—艾普蒂

Rabbit Polyclonal RUFY4 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
RUFY4抗体
英文名称：
Rabbit Polyclonal RUFY4 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4571 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
RUFY4

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesZFYVE31
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human RUFY4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09083(RUFY4 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09083(RUFY4 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于RUFY4抗体的几篇假设性参考文献示例(实际文献需通过学术数据库验证)：

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1. **文献名称**：*RUFY4 regulates autophagosome-lysosome fusion in neuronal cells*

**作者**：Smith A, et al.

**摘要**：研究利用RUFY4抗体揭示其在神经元自噬中的作用，发现RUFY4通过结合LC3蛋白促进自噬体与溶酶体融合，缺失会导致神经退行性病变模型中异常蛋白积累。

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2. **文献名称**：*RUFY4 expression correlates with colorectal cancer metastasis*

**作者**：Li Y, et al.

**摘要**：通过免疫组化(RUFY4抗体)分析结直肠癌组织，发现RUFY4高表达与患者转移风险升高相关，其可能通过调控Wnt/β-catenin通路促进肿瘤侵袭。

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3. **文献名称**：*RUFY4 interacts with Rab7 to modulate endosomal trafficking*

**作者**：Chen H, et al.

**摘要**：研究利用RUFY4抗体进行免疫共沉淀实验，证实RUFY4与Rab7蛋白互作，影响内体运输过程，并参与细胞迁移和免疫突触形成。

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4. **文献名称**：*RUFY4 deficiency impairs mitochondrial clearance in macrophages*

**作者**：Wang X, et al.

**摘要**：在巨噬细胞中敲除RUFY4基因(通过Western blot验证抗体特异性)，发现其缺失导致线粒体自噬障碍，加剧炎症反应和败血症模型中的组织损伤。

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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“RUFY4 antibody”或“RUFY4 function”)。建议结合具体研究方向筛选近期高相关论文。

       

背景信息

The RUFY4 antibody is a research tool designed to detect and study the RUN and FYVE domain-containing protein 4 (RUFY4), a member of the RUFY family involved in intracellular trafficking, autophagy, and immune regulation. RUFY4. also known as Rabip4. is characterized by its RUN domain (associated with GTPase interaction) and FYVE domain (zinc finger motif for membrane binding). It plays roles in endosomal sorting, lysosomal function, and signal transduction pathways, with implications in cancer, neurodegenerative diseases, and immune responses.

Antibodies targeting RUFY4 enable researchers to investigate its expression, localization, and interactions in cells or tissues. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies utilizing RUFY4 antibodies have revealed its involvement in autophagosome-lysosome fusion, cytokine secretion, and receptor recycling. Dysregulation of RUFY4 has been linked to pathologies such as metastasis, inflammation, and impaired autophagy in neurodegenerative conditions.

Due to its specificity, the antibody aids in validating RUFY4’s role in disease models and drug discovery. However, its utility depends on proper validation for cross-reactivity and batch consistency. Ongoing research aims to clarify RUFY4’s mechanistic contributions to cellular homeostasis and its potential as a therapeutic target.

       
RUFY4抗体;RUFY4;RUFY4 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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