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  • NUDT21抗体—艾普蒂
  • NUDT21抗体—艾普蒂
  • NUDT21抗体—艾普蒂

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NUDT21抗体—艾普蒂

Rabbit Polyclonal NUDT21 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
NUDT21抗体
英文名称：
Rabbit Polyclonal NUDT21 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4596 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
NUDT21

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCPSF5; CFIM25
WB Predicted band size26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: HEPG2 and A172 cell, Human fetal brain tissue, Hela, 293T and A431 cell, Primary antibody: P09115(NUDT21 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09115(NUDT21 Antibody) at dilution 1/25. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09115(NUDT21 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于NUDT21抗体的参考文献示例(注：文献为虚构示例，实际引用需根据真实文献调整):

1. **文献名称**: "NUDT21 Regulates Alternative Polyadenylation in Glioblastoma"

**作者**: Smith A, et al.

**摘要**: 本研究利用NUDT21特异性抗体进行免疫沉淀和Western blot分析，揭示其在胶质母细胞瘤中通过调控mRNA 3'端多聚腺苷酸化影响肿瘤细胞增殖的机制。

2. **文献名称**: "CRISPR Screening Identifies NUDT21 as a Cell Cycle Checkpoint Regulator"

**作者**: Johnson B, et al.

**摘要**: 通过NUDT21抗体检测敲低后的蛋白表达，结合功能实验证明其通过结合CCNB1 mRNA影响细胞周期G2/M期转换。

3. **文献名称**: "NUDT21 Antibody Validation for Clinical Biomarker Analysis"

**作者**: Lee C, et al.

**摘要**: 系统性验证NUDT21抗体的特异性(包括敲除/过表达细胞系)，并应用于乳腺癌组织芯片，证实其表达与患者生存率显著相关。

4. **文献名称**: "NUDT21 Interaction Network Revealed by IP-MS"

**作者**: Garcia D, et al.

**摘要**: 使用NUDT21抗体进行免疫沉淀-质谱联用分析，鉴定出与CPSF复合物的相互作用，阐明其在pre-mRNA加工中的核心作用。

建议通过PubMed或Google Scholar以关键词"NUDT21 antibody"+"validation/application"检索最新文献，并优先选择经过抗体验证(如KO验证、应用实验数据)的研究。

       

背景信息

The NUDT21 antibody is a tool used to detect NUDT21 (Nudix Hydrolase 21), also known as CFIm25. a key subunit of the cleavage factor Im (CFIm) complex involved in pre-mRNA 3'-end processing. NUDT21 plays a critical role in mRNA polyadenylation, regulating alternative polyadenylation (APA) sites to influence transcript diversity, stability, and protein expression. Dysregulation of NUDT21 has been linked to cancers, neurological disorders, and viral infections.

NUDT21 antibodies are widely employed in molecular biology research to study its expression, localization, and interactions. They are used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore NUDT21's role in APA-mediated gene regulation, cellular differentiation, and disease mechanisms. For instance, reduced NUDT21 levels correlate with shortened 3' untranslated regions (3'UTRs) in cancer-related genes, promoting oncogenesis. These antibodies also aid in identifying NUDT21's involvement in neurodevelopment and responses to cellular stress.

Commercially available NUDT21 antibodies are typically raised in rabbits or mice against specific epitopes, validated for specificity and sensitivity. Researchers rely on them to dissect post-transcriptional regulatory networks and potential therapeutic targets. Their applications extend to clinical studies, where altered NUDT21 expression serves as a biomarker for disease prognosis or drug response evaluation.

       
NUDT21抗体;NUDT21;NUDT21 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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