CX3CR1抗体;CX3CR1 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using CX3CR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of Jurkat cells using CX3CR1 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of THP-1 cells using CX3CR1 mouse mAb (green) and negative control (red).    

  
  

CX3CR1 is a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, primarily expressed on immune cells such as monocytes, microglia, dendritic cells, and natural killer cells. It binds to its sole ligand, CX3CL1 (fractalkine), a membrane-anchored or soluble chemokine involved in leukocyte migration, adhesion, and immune surveillance. CX3CR1 plays critical roles in neuroinflammation, atherosclerosis, cancer metastasis, and tissue homeostasis, making it a target for studying immune cell behavior in health and disease.

CX3CR1 antibodies are essential tools for detecting receptor expression, tracking cell populations, and investigating signaling pathways. These antibodies are widely used in flow cytometry, immunohistochemistry (IHC), and Western blotting to identify CX3CR1⁺ cells in tissues like the brain, liver, or tumor microenvironments. Specific clones (e.g., 2A9-1. 4L10-G2) recognize epitopes in the extracellular domain, enabling functional studies such as receptor blocking or ligand-binding inhibition. In research, CX3CR1 antibodies help elucidate the receptor’s role in neurodegenerative diseases (e.g., Alzheimer’s, multiple sclerosis) by profiling microglial activation, or in cancer by assessing macrophage polarization. They also aid in validating genetic models, such as CX3CR1-deficient mice, to study disease mechanisms. Due to CX3CR1’s dual roles in immune regulation and pathology, its antibodies are vital for both basic research and therapeutic development, bridging immune function with clinical applications.